33: Heterologous Downregulation of Vasopressin Type 2 Receptor is Induced by Transferrin
نویسندگان
چکیده
منابع مشابه
Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.
Vasopressin (VP) increases urinary concentration by signaling through the vasopressin receptor (V2R) in collecting duct principal cells. After downregulation, V2R reappears at the cell surface via an unusually slow (several hours) "recycling" pathway. To examine this pathway, we expressed V2R-green fluorescent protein (GFP) in LLC-PK1a cells. V2R-GFP showed characteristics similar to those of w...
متن کاملDownregulation of the vasopressin type 2 receptor (V2R) after vasopressin-induced internalization: involvement of a lysosomal degradation pathway
Vasopressin (VP) increases urinary concentration by signaling through the vasopressin receptor (V2R) in collecting duct principal cells. After downregulation, V2R reappears at the cell surface via an unusually slow (several hours) " recycling " pathway. To examine this pathway, we expressed V2R-GFP (green fluorescent protein) in LLC-PK1a cells. V2R-GFP showed similar characteristics to wild typ...
متن کاملLow pH stimulates vasopressin V2 receptor promoter activity and enhances downregulation induced by V1a receptor stimulation.
Arginine vasopressin (AVP) plays a key role in the urine concentration mechanism via the vasopressin V2 receptor (V2R) and aquaporin 2 (AQP2) in the kidney. It is well known that V2R is localized on the basolateral side and the V1a receptor (V1aR) is distributed on the luminal side of the collecting ducts. Previously, we reported an increase of V1aR mRNA and a decrease of V2R mRNA in the collec...
متن کاملRelief of nocturnal enuresis by desmopressin is kidney and vasopressin type 2 receptor independent.
Primary nocturnal enuresis (PNE) is a common problem in childhood and adolescence. Although various treatments are highly effective, a common underlying hypothesis on the pathogenesis is lacking. The success of desmopressin, a synthetic analogue of the antidiuretic hormone vasopressin, has been attributed to increased renal water reabsorption that is mediated by activation of the renal vasopres...
متن کاملRegulation of transferrin receptor 2 protein levels by transferrin.
Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis. In this study, iron-responsive regulation of TfR2 at the protein level was examined in vitro and in vivo. HepG2 cell TfR2 protein levels were up-regulated after exposure to holotransferrin (holoTf) in a time- and dose-responsive mann...
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ژورنال
عنوان ژورنال: American Journal of Kidney Diseases
سال: 2008
ISSN: 0272-6386
DOI: 10.1053/j.ajkd.2008.02.038